The Cardiovascular Research Program (CRP) investigates molecular genetic mechanisms of heart diseases. We focus on discovering new fundamental mechanisms governing cardiac growth and survival, with a special emphasis on transcriptional regulatory networks and epigenetic changes in the diseased heart. The goal of our research is to provide new conceptual frameworks to develop therapies for the treatment of cardiovascular disorders.


Overall achievements

  • By conducting cutting edge and innovative research, the CRP has made important contributions in the field of cardiovascular medicine. Using a variety of methodologies including biochemical, molecular, proteomics and microscopy in cellular systems, animal models and in humans, the CRP has discovered new fundamental mechanisms governing cardiac growth and survival, as well as novel epigenetic mechanisms regulating heart failure.
  • The CRP welcomes and maintains active collaborations with basic and clinical departments at KFSHRC and with institutions in the United States.
  • Research projects are supported by grants funded by King Abdulaziz City for Science and Technology and by Institutional funds.


Selected Publications

Awad Mahmoud S, Aldosari M., Al Yacoub N., Sogaty S, Salih MA, Al Kuraya F., Poizat C. Mutations in PHC1 Implicates Chromatin Remodeling in Primary Microcephaly Pathogenesis. Hum Mol Genet. 2013 Jun 1;22(11):2200-13.

Awad Mahmoud S, Kunhi M, Little GH, Bai Y, An w, Bers D, Kedes L, Poizat C. Nuclear CaMKII Enhances Histone H3 Phosphorylation and Remodels Chromatin During Cardiac Hypertrophy. Nucleic Acids Res. 2013 Sep;41(16):7656-72.

Awad Mahmoud S and Poizat C. Epigenetics & Chromatin Remodeling in Adult Cardiomyopathy. Journal of Pathology, 2013 Oct;231(2):147-57.

Shaheen R, Shamseldin HE, Loucks CM, Seidahmed MZ, Ansari S, Ibrahim Khalil M, Al-Yacoub N, Davis EE, Mola NA, Szymanska K, Herridge W, Chudley AE, Chodirker BN, Schwartzentruber J, Majewski J, Katsanis N, Poizat C, Johnson CA, Parboosingh J, Boycott KM, Innes AM, Alkuraya FS. Mutations in CSPP1, Encoding A Core Centrosomal Protein, Cause A Range of Ciliopathy Phenotypes in Humans. Am J Hum Genet. 2014 Jan 2;94(1):73-9.

Shareef MA, Anwer LA and Poizat C. Cardiac SERCA2A/B: Therapeutic Target for Heart Failure. European Journal of Pharmacology. 2014 Feb 5;724:1-8.

Awad S, Al-Haffar KM, Marashly Q, Quijada P, Kunhi M, Al-Yacoub N, Wade FS, Mohammed SF, Al-Dayel F, Sutherland G, Assiri A, Sussman M, Bers D, Al-Habeeb W, Poizat C. Control of Histone H3 Phosphorylation by CaMKIIδ in Response to Haemodynamic Cardiac Stress. J Pathol. 2015 Mar;235(4):606-18. doi: 10.1002/path.4489. Epub 2014 Dec 17.

Shinwari J, Khan A, Awad SM, Shinwari Z, Alalya A, Alanazi M, Tahir A, Poizat C, Al Tassan N. Recessive Mutations in COL25A1 are a Cause of Congenital Cranial Dysinnervation Disorder. Am J Hum Genet. 2015 Jan 8;96(1):147-52. doi: 10.1016/j.ajhg.2014.11.006. Epub 2014 Dec 11.

Wade FS, Quijada P, Al-Haffar K, Awad SM, Kunhi M, Toko H, Marashly Q, Belhaj K, Stanford SM, Alvarez R, Liu Y, Dilek Colak, Jordan MC, Roos KP, Al-Habeeb W, Sussman MA, Bottini N and Poizat C. Deletion of Low Molecular Weight Protein Tyrosine Phosphatase (Acp1) Protects Against Stress-Induced Cardiomyopathy. J Pathol. 2015 Jul 25. doi: 10.1002/path.4594. [Epub ahead of print]

QuijadaP, Hariharan N, CubilloJ, Bala K.M, Emathinger JM, Wang BJ, OrmacheaL, Bers D, Sussman M and Poizat C. Nuclear Calcium/Calmodulin-Dependent Protein Kinase II Signaling Enhances Cardiac Progenitor Cell Survival and Cardiac Lineage Commitment. J Biol Chem. 2015 Oct 16;290(42):25411-26.

Alazami AM, Mahmoud SA, Coskun S, Al-Hassan S, Hijazi H, Abdulwahab F, Poizat C*, Alkruaya FS*. TLE6 Mutation Causes the Earliest Known Human Embryonic Lethality. Genome Biology. Genome Biol. 2015 Nov 5;16(1):240. * co-corresponding authors.

Al-Yacoub N, Shaheen, R, Awad SM, Kunhi M, Dzimiri N, Nguyen HC, Xiong Y, Al-Habeeb W, Alkuraya FS, Poizat C. FBXO32(ATROGIN1), encoding a member of the SCF complex, is mutated in dilated cardiomyopathy. Genome Biology. Accepted.


Coralie Poizat, PhD

Senior Scientist & Director
Cardiovascular Research Program-Room B58
KFSHRC - Research Centre
Phone:(966) 1 464 7272, Ext 32984

Abdullah Al-Kulaib                                                                 

Administrative Assistant
Cardiovascular Research Program-Room B58B
KFSHRC - Research Centre
Phone:(966) 1 464 7272, Ext 70153




Accreditations & Awards