EPIGENETIC OF HEART FAILURE SECTION - RIYADH

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Cardiac hypertrophy is an adaptive response of the heart to a variety of pathological insults, which involves an increase in cardiac mass paralleled by a reprogramming of cardiac gene expression. We are actively engaged in understanding the role of specific isoforms of calcium/calmodulin-dependent protein kinases (CaMK) in pathological hypertrophy. We use a combination of biochemical approaches, transcription assays, fluorescence microscopy and genome-wide methods to understand how nuclear CaMK signals to the genome to alter gene expression and regulate hypertrophic growth. We also use viral gene delivery and siRNA technology in primary cultures of cardiomyocytes, and also perform studies in human explanted hearts.

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