Title and Dept: Post-doctoral fellow, Cardiovascular Research Program
1) Epigenetic regulation of heart development and cardiomyopathies.
2) Understanding the mechanisms of action of the protein complexes that regulate gene expression of cardiac genes by modifying the structure of chromatin. Description: Heart development is orchestrated by a complex and precise network of genes that govern developmental decisions. However, the detailed understanding of how gene expression patterns are coordinated during developmental/disease transitions the cardiac cells is not well characterized. In the Cardiovascular Research Program (CRP) we are interested in understanding how chromatin modifying proteins work in turning cardiac genes “on” or “off”. Since many subunits of these chromatin-modifying proteins have been implicated in the initiation of various cardiovascular diseases, it is likely that errors in the function of these protein complexes may trigger the development of cardiomyopathies.