Anti-Cancer Potential of Eugenoplatin

Platinum-based chemotherapeutic drugs have been widely used for the treatment of various cancers. We have recently synthesized a phyto-chemo drug conjugate composed of cisplatin and eugenol, two molecules with synergistic anti-cancer effects. This novel genotoxic molecule (eugenoplatin) has shown higher cytotoxicity through induction of apoptosis via the mitochondrial pathway, and strong inhibition of cell growth via cell cycle delay at G2/M phase in different cell lines. Importantly, eugenoplatin can target cancer stem cells in various cancer cell lines, with only marginal nephrotoxicity. Our major goals are to show the anti-cancer effects of this novel molecule both in vitro and in animal models in various types of cancer. We will also determine the molecular targets and the pharmacokinetics and pharmacodynamics of eugenoplatin. The ultimate goal is the identification of a potent anti-cancer drug with fewer side effects, which could be of great therapeutic value for millions of patients.

Ibrahim Al-Jammaz, Noura Alraouji, Basem Al-Otaibi, Falah Al-Mohanna, Layla Al-kharashi.