Genomics of Adrenocortical Carcinoma

This project seeks to perform a comprehensive genomic characterization of adrenocortical carcinoma (ACC) in the Saudi Arabian population, a rare but highly aggressive endocrine malignancy with limited therapeutic options. Although genomic studies in Western populations have identified recurrent alterations in genes such as TP53, CTNNB1, ZNRF3, and IGF2, there is no genomic data available for ACC patients in Saudi Arabia. Considering the unique genetic background and high rates of consanguinity in the region, uncovering population-specific mutations and pathways is crucial for improving diagnosis and treatment. Through next-generation sequencing of tumor and matched normal tissues, this study will define the mutational landscape and identify potential diagnostic and prognostic biomarkers.

The expected impact includes enhanced understanding of disease biology in Saudi patients, improved molecular stratification, and the identification of novel therapeutic targets. Ultimately, this work will support precision medicine approaches and strengthen national cancer care.