Ali Saeed Saad Alzahrani

A Consultant Endocrinologist at King Faisal Specialist Hospital & Research Centre in Riyadh, leading the development of a comprehensive multidisciplinary Endocrine Oncology program encompassing thyroid, adrenal, pituitary, and neuroendocrine tumors.

His clinical and translational research focuses on thyroid cancer biology and therapeutics, genetic endocrinology, and the genomics of the adrenal gland, pancreas, parathyroid glands, hypothalamus, and pituitary, with a particular emphasis on Saudi-specific cohorts that leverage the region’s unique epidemiological landscape.

He has authored numerous peer-reviewed publications and collaborates extensively with national and international partners to integrate precision oncology into routine clinical care, including omics technologies, molecular tumor boards, and biobanking. He has also led multidisciplinary initiatives aimed at expanding access to care, standardizing molecular testing workflows, and accelerating the translation of research discoveries from bench to bedside.

His current projects include Saudi cohort studies in endocrine oncology, optimization of targeted therapies for radioiodine-refractory thyroid cancer, anaplastic thyroid cancer and advanced genomic investigations of pituitary and adrenal tumors. He is deeply committed to workforce development through the mentorship of clinical medical fellows within the Endocrine Oncology Program, as well as PhD and Master’s students in Molecular Endocrinology, and to the establishment of sustainable research infrastructure aligned with national health and innovation priorities.

Thyroid Cancer Biology and Therapeutics.

Endocrine Oncology.

Genetic of Endocrine.

Comprehensive Genomic Profiling of Pheochromocytomas and Paragangliomas: Implications for Hereditary Risk, Phenotypic Expression, and Therapy.

Comprehensive Genomic Analysis of Pituitary Adenomas: Toward Personalized Management Strategies.

Population Prevalence of Cancer-Associated Genes and Syndromes in Saudi Arabia.

Molecular Genetics of the Maturity-Onset Diabetes of the Young (MODY) in Saudi Arabia.

More than two decades of extensive clinical and research experience, he is an internationally recognized leader in endocrine oncology. He obtained his MBBS from King Saud University, completed internal medicine residency training at KFSH&RC, and pursued clinical and research endocrinology fellowship training at Johns Hopkins University, where he also served as a Visiting Scientist, in addition to a visiting appointment at Memorial Sloan Kettering Cancer Center (MSKCC). He has authored more than 200 peer-reviewed publications, with over 8,000 citations and an H-index of 42 in 2025. He currently leads the Molecular Endocrinology Laboratory at KFSH&RC, Riyadh, and previously served as Executive Director of the Research Centre. His work focuses on thyroid, adrenal, pituitary, and neuroendocrine tumors, emphasizing molecular genetics, precision oncology, and Saudi-specific cohorts integrated into multidisciplinary clinical care. He has held prominent editorial and leadership roles, including Editor-in-Chief of Annals of Saudi Medicine, Academic Editor at PLOS One, and associate editor of the Journal of Clinical Endocrinology and Metabolism (JCEM), and Endocrine-Related Cancer, and enditorial board member of THYROID, Endocrine, and JCEMCR.