Paraben Exposure and Breast Density

This cross-sectional study investigates the potential link between paraben exposure and mammographic breast density, an established predictor of breast cancer risk among women aged 40 and above in Saudi Arabia. Parabens, widely used as preservatives in personal care products, food, and pharmaceuticals, have been identified in breast tumors and are suspected endocrine-disrupting chemicals (EDCs). Despite increasing international concern, limited data are available on their impact on Middle Eastern populations.

The study recruits 400 women undergoing routine mammographic screening at King Faisal Specialist Hospital & Research Centre (KFSHRC). Each participant provides a urine sample to measure levels of four specific parabens (methyl, ethyl-, propyl-, and butyl-paraben) using a validated UHPLC-MS/MS protocol. Breast density will be assessed from mammography images using standard ACR classification. Data on lifestyle and product use are collected through structured questionnaires.

By uncovering potential modifiable environmental risk factors for breast cancer, this project aims to raise public awareness, guide regulatory policies on chemical safety in consumer products, and inform early prevention strategies tailored to the local population. It is the first such study in Saudi Arabia and will serve as a foundation for broader investigations into endocrine disruptors and women's health.