Trace Metals and NAFLD Risk

This case-control study investigates the possible role of excess or deficiency of essential trace metals, particularly copper, zinc, selenium, manganese, and iron, in the pathogenesis and progression of non-alcoholic fatty liver disease (NAFLD) among adults in Saudi Arabia. NAFLD is one of the most common causes of chronic liver disease worldwide, with increasing prevalence linked to lifestyle and metabolic disorders. However, emerging evidence suggests that environmental and nutritional metal imbalances may also play a significant role.

The study will recruit NAFLD patients diagnosed by imaging, along with matched healthy controls. Urine and blood samples will be analyzed using ICP-MS to determine trace metal concentrations. Comprehensive biochemical and anthropometric parameters will also be evaluated. The aim is to identify potential patterns of trace metals associated with NAFLD severity and metabolic outcomes.

The results may provide insights into the environmental and nutritional determinants of liver health, guiding early intervention strategies and dietary recommendations for populations at high risk of metabolic liver disorders.