Single-Cell Multi-Omics in Saudi Cancer

This proposal aims to leverage cutting-edge single-cell sequencing, multi-omics, and spatial multi-omics technologies—complemented by microbiome analysis—to uncover novel biomarkers, therapeutic targets, and mechanisms of cancer progression and treatment response. By studying diverse cancers (breast, colorectal, ovarian, lung, and prostate) in a Saudi Arabian cohort, the project will investigate the interplay between tumor genomics and the host microbiome, particularly its influence on drug metabolism and therapy outcomes. Patient samples, including biopsies and blood, will undergo integrated molecular profiling to address cancer heterogeneity at the genomic, transcriptomic, proteomic, and epigenetic levels. This research is expected to advance precision oncology and support early diagnosis and personalized treatment strategies. Furthermore, it aims to accelerate Saudi Arabia’s leadership in genomic medicine, fostering clinical translation and local capacity in omics-driven cancer care.

Andrew McBain.