The researchers at the Human Cancer Genomic Research (HCGR) continue to pursue the challenges in the field of Cancer Research and working on their mission which is to conduct translational research on concerns that are more prevalent in the Kingdom of Saudi Arabia. In the year 2014, the program continued to be an integral part of the International Cancer Genome Consortium (ICGC) for analyzing papillary thyroid cancer in the Kingdom of Saudi Arabia. They were able to investigate the role of mTOR signaling pathway in PYC and finally, they found a very low level of BRAF mutation in colorectal carcinoma in this region.
The main goal of the Human Cancer Genomic Research (HCGR) is to recognize or categorize the dysregulation in various genes and signaling pathways in those cancers that are most prevalent in the Kingdom of Saudi Arabia. The other main focus of HCGR is also to perform high-quality translational research using state-of-the-art technologies, including high-throughput third-generation sequencing analysis. The scientists and other researchers of HCGR lab continue their research in pursuing these challenges by performing translation studies to identify molecular and genetic that may be playing a role in the pathogenesis of these cancers by also using latest techniques to investigate the function of genes that have been implicated in the pathogenesis of various malignancies.
The section provides bioinformatics support to the department with the main focus on management, integration and analysis of next-generation sequencing data. The section has state of the art tools, software and computational facility for catering the needs of the department besides having large storage servers for data safety and backup. With our inbuilt pipelines, methods and expertise, we mine the useful knowledge from high-throughput data.
The section is well equipped with the following types of bioinformatics and high-throughput sequencing analyses:
The main function of the Biological Repository Centre (BRC) is the proper preservation & storage of archival frozen tumor and normal tissue samples. In addition, DNA and RNA extraction from these frozen samples is also done that are utilized for mutational analysis and differential expression studies in various projects. The functions of the BRC include: