Micronutrients in HNC Radiotherapy

This prospective observational study aims to evaluate the association between the status of selected micronutrients (vitamins and trace elements) and treatment-related toxicities and clinical outcomes in patients with head and neck cancer (HNC) undergoing radiotherapy. HNC is a major global health concern, with high morbidity and treatment-related complications, often exacerbated by malnutrition and oxidative stress.

The study will include all adult patients diagnosed with HNC and scheduled for curative-intent radiotherapy. Blood and urine samples will be collected before and after treatment to measure levels of vitamins A, C, D, E, B6, B12, and folate, as well as trace elements including selenium, zinc, and copper. Additionally, markers of oxidative stress and inflammation (e.g., 8-OHdG, malondialdehyde, C-reactive protein) will be assessed.

Clinical data will be collected on treatment toxicity (e.g., mucositis, dermatitis, dysphagia), treatment interruptions, and disease response. The study will also examine correlations between micronutrient levels and adverse events, progression-free survival, and overall survival.

By identifying micronutrient deficiencies associated with poor tolerance to radiotherapy and worse clinical outcomes, the findings may support the development of nutritional interventions aimed at improving the quality of care and treatment efficacy in HNC patients. This project aligns with public health goals to reduce the burden of cancer and enhance supportive care strategies.