Research Services
Khalid Abu Khabar Alqurashi
Our research group aims to develop deeper insights into the mechanisms of mRNA stability in disease, and harness this knowledge for the benefit of patients and the biotech industry.
Overview
Cancer and chronic inflammatory conditions are a major health and economic burden in Saudi Arabia. We conduct innovative research with experimental and computational models to study mRNA stability-driven disease mechanisms in invasive cancer and inflammation, and translate experimental data into impactful biomarkers and therapies.
Developing deeper insights into the mechanisms of mRNA stability in disease
Our group develops novel experimental approaches that enable us to investigate, in the laboratory, the disease mechanisms comprising mRNA decay and protein translation, with promising clinical and biotech applications.
We have developed a unique mRNA optimisation method to increase mRNA stability, which can be applicable to both gene and RNA therapeutics. Our post-transcriptional technology platform utilizes our uniquely and optimally designed reporter systems, including fluorescence, phosphorylation, and chemiluminescence, to track changes in mRNA decay in cells or tissues.
Furthermore, we developed a novel concept based on UU/UA dinucleotide frequency and its influence on mRNA stability, and have applied it to immune-oncology and chemotherapy responses in colon and lung cancer. More recently, we use AI-enabled and bioinformatics algorithms to decipher RNA-omics and drive meaningful discoveries.
Our Team
A dedicated group advancing mRNA research and its clinical impact.
Khalid Abu Khabar Alqurashi
Principal Scientist / Group Leader
Edward Hitti
Senior Scientist
Tala Bakheet
Scientist
Projects
Innovative studies on mRNA stability driving precision medicine and therapies.
Beta Version