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Overview

Dr. Ayodele A. Alaiya is a Principal Scientist at King Faisal Specialist Hospital & Research Centre, where he leads biomarker innovation initiatives for clinical applications. He is an internationally recognized expert in clinical proteomics and translational biomarker discovery, with over two decades of experience integrating advanced proteomic technologies with patient-centered research. His work focuses on the discovery and clinical translation of protein biomarkers for cancer, cardiovascular diseases, neurosciences, infectious diseases, and organ transplantation. Using state-of-the-art mass spectrometry, targeted proteomics, and integrative multi-omics platforms, he develops diagnostic and prognostic tools that support early detection, risk stratification, and personalized treatment strategies. Dr. Alaiya has authored more than 70 peer-reviewed publications and established advanced proteomics platforms that directly contribute to precision medicine and improved patient outcomes.

Fields of Expertise

Clinical Proteomics and Mass Spectrometry.

Biomarker Discovery and Clinical Translation.

Translational Oncology.

Stem Cell Therapy and Regenerative Medicine.

Precision and Personalized Medicine.

Molecular Diagnostics.

Multi-omics Data Integration.

Career Background

Dr. Alaiya holds degrees in Medicine, Public Health, and Experimental Oncology, and is a Fellow of the Royal College of Pathologists (United Kingdom). He earned his PhD from Karolinska Institutet, Sweden, and has held senior scientific and leadership roles at King Faisal Specialist Hospital & Research Centre, including Director of the Stem Cell and Tissue Re-Engineering Program and Chairman of the Cell Therapy and Immunobiology Department. He is also a long-standing Visiting Scientist at the Cancer Center, Karolinska Institutet. Throughout his career, he has established advanced proteomics units, led translational research programs, secured competitive research funding, and supervised postgraduate trainees across multiple international institutions.

Publications

1. Mistry B, Alaiya A, Abu-Dawud R, Alyacoub N, Colak D, Rajab M, Alanazi M, Shinwari Z, Ahmed H, Alharbi T, Kashir J, Almohanna F, Assiri A. Investigation of testis proteome alterations associated with male infertility in Dcaf17-deficient mice. Syst Biol Reprod Med. 2025 Dec;71(1):206-228; Impact Factor: 2.6; Doi: 10.1080/19396368.2025.2504459. Epub 2025 May 31. PubMed PMID: 40449516.

2. Gaafar A, Hamza FN, Yousif R, Shinwari Z, Alotaibi AG, Iqniebi A, Al-Hussein K, Al-Mazrou A, Manogaran PS, Elhassan T, Marquez-Méndez M, Aljurf M, Al-Humaidan H, Alaiya A. Distinct Phenotypic and Molecular Characteristics of CD34(-) and CD34(+) Hematopoietic Stem/Progenitor Cell Subsets in Cord Blood and Bone Marrow Samples: Implications for Clinical Applications. Diagnostics (Basel). 2025 Feb 12;15(4); Impact Factor: 3.3; Doi: 10.3390/diagnostics15040447. PubMed PMID: 40002599; PubMed Central PMCID: PMC11853955.

3. Beg MA, Ismail AO, Alaiya A, Khan FA, Hamoda TAA, Sheikh IA, Sharma P, Baothman OM, Alkhzaim AH, Shinwari Z, Abuzinadah RF, Mohammed A, Assiri AM, Abuzenadah AM, Memili E, Feugang JM. Age-Associated Proteomic Changes in Human Spermatozoa. Int J Mol Sci. 2025 Jun 25;26(13):6099; Impact Factor: 5.7; Doi: 10.3390/ijms26136099. PMID: 40649876; PMCID: PMC12249680.

4. AlZahrani S, Shinwari Z, Alaiya A, Al-Kahtani A. Impact of Resolvin-E1 and Maresin-1 on Bone Marrow Stem Cell Osteogenesis under Inflammatory Stress. Cells. 2024 May 28;13(11). doi: 10.3390/cells13110932. PubMed PMID: 38891064; PubMed Central PMCID: PMC11171860.

5. Alaiya A, Alharbi BM, Shinwari Z, et al. Proteomics Analysis of Proteotoxic Stress Response in In-Vitro Human Neuronal Models. Int J Mol Sci. 2024;25(12).

6. Alraouji NN, Colak D, Al-Mohanna FH, Alaiya AA, Aboussekhra A. Endogenous osteoprotegerin (OPG) represses ERalpha and promotes stemness and chemoresistance in breast cancer cells. Cell Death Discov. 2024;10(1):377.

7. Dandachi I, Alaiya A, Shinwari Z, et al. Proteomic Profiling of COVID-19 Patients Sera: Differential Expression with Varying Disease Stage and Potential Biomarkers. Diagnostics (Basel). 2024;14(22).

8. Elfoly M, Mirza JY, Alaiya A, Al-Hazzani AA, Tulbah A, Al-Alwan M, Ghebeh H. PD-L1 intrinsically promotes the proliferation of breast cancer cells through the SKP2-p27/p21 axis. Cancer Cell Int. 2024 May 9;24(1):161. doi: 10.1186/s12935-024-03354-w. PubMed PMID: 38725021; PubMed Central PMCID: PMC11084005.

9. Al-Mutairy EA, Al Qattan S, Khalid M, Al-Enazi AA, Al-Saif MM, Imtiaz F, Ramzan K, Raveendran V, Alaiya A, Meyer BF, Atamas SP, Collison KS, Khabar KS, Hasday JD, Al-Mohanna F. Wild-type S100A3 and S100A13 restore calcium homeostasis and mitigate mitochondrial dysregulation in pulmonary fibrosis patient-derived cells. Front Cell Dev Biol. 2023;11:1282868. doi: 10.3389/fcell.2023.1282868. eCollection 2023. PubMed PMID: 38099297; PubMed Central PMCID: PMC10720433.

10. Gallo-Oller G, de Stahl TD, ̊ Alaiya A, Nilsson S, Holmberg AR, Márquez-Méndez M. Cytotoxicity of polyguanidine in medulloblastoma cell lines. Invest New Drugs. 2023 Oct;41(5):688-698. doi: 10.1007/s10637-02301386-z. Epub 2023 Aug 9. PubMed PMID: 37556022; PubMed Central PMCID: PMC10560188.

11. Alkhayal Z, Shinwari Z, Gaafar A, Alaiya A. Fluconazole-Induced Protein Changes in Osteogenic and Immune Metabolic Pathways of Dental Pulp Mesenchymal Stem Cells of Osteopetrosis Patients. Int J Mol Sci. 2023 Sep 8;24(18). doi: 10.3390/ijms241813841. PubMed PMID: 37762144; PubMed Central PMCID: PMC10531073.

12. Al-Dhfyan A, Alaiya A, Al-Mohanna F, Attwa MW, AlAsmari AF, Bakheet SA, Korashy HM. Crosstalk between aryl hydrocarbon receptor (AhR) and BCL-2 pathways suggests the use of AhR antagonist to maintain normal differentiation state of mammary epithelial cells during BCL-2 inhibition therapy. J Adv Res. 2023 Aug;50:177192. doi: 10.1016/j.jare.2022.10.006. Epub 2022 Oct 26. PubMed PMID: 36307019; PubMed Central PMCID: PMC10403657.

13. Giha HA, Abdulwahab RA, Abbas J, Shinwari Z, Alaiya A. Sex-Biased Expression of Genes Allocated in the Autosomal Chromosomes: Blood LC-MS/MS Protein Profiling in Healthy Subjects. Genet Res (Camb). 2023;2023:8822205. doi: 10.1155/2023/8822205. eCollection 2023. PubMed PMID: 36941947; PubMed Central PMCID: PMC10024626.

14. Alkhayal Z, Shinwari Z, Gaafar A, Alaiya A. Carbonic Anhydrase II Activators in Osteopetrosis Treatment: A Review. Curr Issues Mol Biol. 2023 Feb 6;45(2):1373-1386. doi: 10.3390/cimb45020089. Review. PubMed PMID: 36826034; PubMed Central PMCID: PMC9954968.

15. Alaskar A, Abdulraqeb Ali A, Hassan S, Shinwari Z, Alaiya A, von Holzen U, Miller L, Kulik G. Inhibition of signaling downstream of beta-2 adrenoceptor by propranolol in prostate cancer cells. Prostate. 2023 Feb;83(3):237245. doi: 10.1002/pros.24455. Epub 2022 Nov 14. PubMed PMID: 36373761; PubMed Central PMCID: PMC10100053.

16. Janssen E, Alosaimi MF, Alazami AM, Alsuliman A, Alaiya A, Al-Saud B, Al-Mousa H, Al-Zaid TJ, Smith E, Platt CD, Alruwaili H, Albanyan S, Al-Mayouf SM, Geha RS. A homozygous truncating mutation of FGL2 is associated with immune dysregulation. J Allergy Clin Immunol. 2023 Feb;151(2):572-578.e1. doi: 10.1016/j.jaci.2022.10.006. Epub 2022 Oct 13. PubMed PMID: 36243222.

17. AlZahrani S, Shinwari Z, Gaafar A, Alaiya A, Al-Kahtani A. Anti-Inflammatory Effect of Specialized Proresolving Lipid Mediators on Mesenchymal Stem Cells: An In Vitro Study. Cells. 2022 Dec 28;12(1). doi: 10.3390/cells12010122. PubMed PMID: 36611915; PubMed Central PMCID: PMC9818697.

18. Abu-Dawud R, Mistry BV, Almahdali R, Matin MM, Alaiya A, Alghamdi F, Alamari H, Al-Yacoub N, Kashir J, Houssein M, Alawad A, Andrews PW, Assiri AM. Dynamic cytosolic foci of DPPA4 in human pluripotent stem cells. Tissue Cell. 2022 Oct;78:101893. doi: 10.1016/j.tice.2022.101893. Epub 2022 Aug 9. PubMed PMID: 36007377.

19. Márquez M, Olausson KH, Alaiya A, Nilsson S, Meurling L, Holmberg AR. Poly-guanidine shows high cytotoxicity in glioma cell cultures and glioma stem cells. Invest New Drugs. 2022 Jun;40(3):565- 575. doi: 10.1007/s10637-022-01233-7. Epub 2022 Mar 21. PubMed PMID: 35312943; PubMed Central PMCID: PMC9098561.

20. Jacob M, Masood A, Shinwari Z, Abdel Jabbar M, Al-Mousa H, Arnaout R, AlSaud B, Dasouki M, Alaiya AA, Abdel Rahman AM. Proteomics Profiling to Distinguish DOCK8 Deficiency From Atopic Dermatitis. Front Allergy. 2021;2:774902. doi: 10.3389/falgy.2021.774902. eCollection 2021. PubMed PMID: 35386989; PubMed Central PMCID: PMC8974780.

21. Alaiya A, Alshukairi A, Shinwari Z, Al-Fares M, Alotaibi J, AlOmaim W, Alsharif I, Bakheet R, Alharbi L, Allam R, Asiri A, Memish Z, Alromaih K, Al-Mozaini M. Alterations in the Plasma Proteome Induced by SARS-CoV-2 and MERS-CoV Reveal Biomarkers for Disease Outcomes for COVID-19 Patients. J Inflamm Res. 2021;14:43134328. doi: 10.2147/JIR.S322430. eCollection 2021. PubMed PMID: 34511970; PubMed Central PMCID: PMC8421783.

22. Al-Qahtani QH, Moghrabi WN, Al-Yahya S, Al-Haj L, Al-Saif M, Mahmoud L, Al-Mohanna F, Al- Souhibani N, Alaiya A, Hitti E, Khabar KSA. Kinome inhibition reveals a role for polo-like kinase 1 in targeting posttranscriptional control in cancer. Mol Oncol. 2021 Aug;15(8):2120-2139. doi: 10.1002/1878-0261.12897. Epub 2021 Feb 1. PubMed PMID: 33411958; PubMed Central PMCID: PMC8334256.

23. Al-Mozaini M, Alzahrani A, Alsharif I, Shinwari Z, Halim M, Alhokail A, Alrajhi A, Alaiya A. Quantitative proteomics analysis reveals unique but overlapping protein signatures in HIV infections. J Infect Public Health. 2021 Jun;14(6):795-802. doi: 10.1016/j.jiph.2021.03.009. Epub 2021 Mar 29. PubMed PMID: 34030014.

24. Dasouki M, Alaiya A, ElAmin T, Shinwari Z, Monies D, Abouelhoda M, Jabaan A, Almourfi F, Rahbeeni Z, Alsohaibani F, Almohareb F, Al-Zahrani H, Guzmán Vega FJ, Arold ST, Aljurf M, Ahmed SO. Comprehensive multi-omics analysis of G6PC3 deficiency-related congenital neutropenia with inflammatory bowel disease. iScience. 2021 Mar 19;24(3):102214. doi: 10.1016/j.isci.2021.102214. eCollection 2021 Mar 19. PubMed PMID: 33748703; PubMed Central PMCID: PMC7960940.

25. Alkhayal Z, Shinwari Z, Gaafar A, Alaiya A. Proteomic Profiling of the First Human Dental Pulp Mesenchymal Stem/Stromal Cells from Carbonic Anhydrase II Deficiency Osteopetrosis Patients. Int J Mol Sci. 2020 Dec 31;22(1). doi: 10.3390/ijms22010380. PubMed PMID: 33396517; PubMed Central PMCID: PMC7795265.

26. Barnawi R, Al-Khaldi S, Bakheet T, Fallatah M, Alaiya A, Ghebeh H, Al-Alwan M. Fascin Activates β- Catenin Signaling and Promotes Breast Cancer Stem Cell Function Mainly Through Focal Adhesion Kinase (FAK): Relation With Disease Progression. Front Oncol. 2020;10:440. doi: 10.3389/fonc.2020.00440. eCollection 2020. PubMed PMID: 32373510; PubMed Central PMCID: PMC7186340.

27. Basmaeil YS, Algudiri D, Alenzi R, Al Subayyil A, Alaiya A, Khatlani T. HMOX1 is partly responsible for phenotypic and functional abnormalities in mesenchymal stem cells/stromal cells from placenta of preeclampsia (PE) patients. Stem Cell Res Ther. 2020 Jan 21;11(1):30. doi: 10.1186/s13287-020-1557-6. PubMed PMID: 31964423; PubMed Central PMCID: PMC6975087.

Patents

1. Walid Warda, Farhatullah Syed, Syed Osman Ahmed, Ayodele Alaiya, Hazaa Alzahrani, Hanan Alqudairy: T-CELLS COMPRISING CHIMERIC ANTIGEN RECEPTORS AND COMPOSITIONS THEREOF FOR TREATMENT OF CANCER, Application Number: US19/059,099, Filed: 02/20/2025.
Projects
Beta Version