Abdelilah Aboussekhra

1. Syed S Islam, Taher Al-Tweigeri, Asma Tulbah, Saleh N Najjar, Sarah S Aljohani, Layla Al-Harbi, Ahmed M Gad, Shafat Ujjahan, Abdelilah Aboussekhra. A long noncoding RNA-based serum signature predicts ado-trastuzumab emtansine (T-DM1) treatment benefit in HER2+ metastatic breast cancer patients: a multicenter cohort study. Cell Death Discov. 2025 Sep 9;11(1):421.doi: 10.1038/s41420-025-02701-8.

2. Alnwisser B, Alshehri S, Qattan A, Zou M, Aboussekhra A, Alzahrani AS, Shi Y. Front Oncol. Identification of novel prognostic biomarkers for thyroid cancer by integrated transcriptome analysis of metastasis-associated genes. 2025 May 19;15:1536270. doi: 10.3389/fonc.2025.1536270. eCollection 2025.

3. Naser Elkum, Abdelilah Aboussekhra, Mouad Aboussekhra, Hanin Aldalham, Lama Alshehri, Saleh Alessy, Taher Al-Tweigeri, Ali Saeed Al-Zahrani. Molecular Subtypes of Breast Cancer in Arab Women: Distribution and Prognostic Insights. J Epidemiol Glob Health. 2025, Mar 10;15(1):36. doi: 10.1007/s44197-025-00376-z.

4. Sayer Al-Harbi, Elham MA Alkholiwy, Syed Osman Ali Ahmed, Mahmoud Aljurf, Reem Al-Hejailan, Abdelilah Aboussekhra. Eugenol promotes apoptosis in leukemia cells via targeting the mitochondrial biogenesis PPRC1 gene. Cells, 2025, Feb 12;14(4):260. doi: 10.3390/cells14040260.

5. Minjing Zou, Amal Qattan, Monther Al-Alwan, Hazem Ghebeh, Naif Binjumah, Latifa Al-Haj, Khalid S A Khabar, Abdulmohsen Altaweel, Falah Almohanna, Abdullah M Assiri, Abdelilah Aboussekhra, Ali S Alzahrani, and Yufei Shi. Genome-wide transcriptome analysis and drug target discovery reveal key genes and pathways in thyroid cancer metastasis. Front Endocrinol. 2025, Feb 10;16:1514264. doi: 10.3389/fendo.2025.1514264.

6. Layla A. Al-Kharashi, Falah H. Al-Mohanna and Abdelilah Aboussekhra. E2F1 activates breast stromal fibroblasts and promotes their paracrine pro-carcinogenic effects. Sci Rep. 2025, Feb 4;15(1):4210. doi: 10.1038/s41598-025-87808-9.

7. Syed S Islam, Falah H Al-Mohanna , Iman M Yousef , Ismail A Al-Badawi , Abdelilah Aboussekhra. Ovarian tumor cell-derived JAGGED2 promotes omental metastasis through stimulating the Notch signaling pathway in the mesothelial cells. Cell Death Dis. (2024) Apr 4;15(4):247. doi: 10.1038/s41419-024-06512-0.

8. Jamilah H. Alshehri, Huda K. Al-Nasrallah, Mysoon M. Al-Ansari, and Abdelilah Aboussekhra Activation of mammary epithelial and stromal fibroblasts upon exposure to E.coli metabolites. Cells, (2024), 17;13(20):1723. doi: 10.3390/cells13201723.

9. Noura N Alraouji, Dilek Colak, Falah H. Al-mohanna, Ayodele A. Alaiya, and Abdelilah Aboussekhra. Endogenous osteoprotegerin (OPG) represses ERa and promotes stemness and chemoresistance in breast cancer cells. Cell Death Discov. (2024), 24;10(1):377. doi: 10.1038/s41420-024-02151-8.

10. Islam SS, Al-Tweigeri T, Al-Harbi L, Ujjahan S, Al-Mozaini M, TulbahA, Aboussekhra A. Long noncoding RNA DLEU2 and ROR1 pathway induces epithelial-to-mesenchymal transition and cancer stem cells in breast cancer. Cell Death Discov. (2024) 31;10(1):61. doi: 10.1038/s41420-024-01829-3.

11. Wafaa A Aljagthmi, Manal A Alasmari, Maha H Daghestani, Layla A Al-Kharashi, Falah H Al-Mohanna, Abdelilah Aboussekhra. Decorin (DCN) Downregulation Activates Breast Stromal Fibroblasts and Promotes Their Pro-Carcinogenic Effects through the IL-6/STAT3/AUF1 Signaling. Cells, (2024) 14;13(8):680. doi: 10.3390/cells13080680.

12. Abdelilah Aboussekhra, Noura N. Alraouji, Falah Al-Mohanna, Huda Al-Khalaf. Ionizing radiation normalizes the features of active breast cancer stromal fibroblasts and suppresses their paracrine pro-carcinogenic effects. Transl Oncol. (2023):37:101780. doi: 10.1016/j.tranon.2023.101780.

13. Aboussekhra A, Islam SS, Alraouji NN. Activated breast stromal fibroblasts exhibit myoepithelial and mammary stem cells features. Transl Oncol. (2023), Sep:35:101721. doi: 10.1016/j.tranon.2023.101721.

14. Islam SS, Karakas B, Aboussekhra A, Noman ASM. KEAP1/NRF2 Mutations in Stem Cells Define an Aggressive Subset of Head and Neck Cancer Patients Who Have a Poor Prognosis, Lung Metastasis, and Therapeutic Failure. Cancers, (2023), 15(20):5006. doi: 10.3390/cancers15205006.

15. Mai Al-Mohanna, Noura N. Alraouji, Samiah A. Alhabardi, Falah Almohanna, Basem Al-Otaibi, Ibrahim AlJammaz and Abdelilah Aboussekhra. The curcumin analogue PAC has potent anti-anaplastic thyroid cancer effects. Scientific Reports. (2023), 14;13(1):4217. doi: 10.1038/s41598-023-30888-2.

16. Taher Al-Tweigeri, Noura N. AlRaouji, Asma Tulbah, Maria Arafah, Mouad Aboussekhra, Falah AlMohanna, Ahmed Mostafa Gad, Abdelmonneim M. Eldali, Tusneem A. Elhassan, and Abdelilah Aboussekhra. High AUF1 level in stromal fibroblasts promotes carcinogenesis and chemoresistance and predicts unfavorable prognosis among locally advanced breast cancer patients. Breast Cancer Res. 24, 46 (2022). https://doi.org/10.1186/s13058-022-01543-x.

17. Al-Nasrallah HK, Al-Ansari MM, Aboussekhra A. Osteoprotegerin (OPG) Upregulation Activates Breast Stromal Fibroblasts and Enhances Their Pro-Carcinogenic Effects through the STAT3/IL-6 Signaling. Cells. (2022), 25;11(21):3369. doi:10.3390/cells11213369.

18. Al-Kharashi LA, Tulbah A, Arafah M, Eldali AM, Al-Tweigeri T, Aboussekhra A. High DNMT1 expression in stromal fibroblasts promotes angiogenesis and unfavorable outcome in locally advanced breast cancer patients. Front Oncol. (2022), Jun 2;12:877219. doi: 10.3389/fonc.2022.877219.

19. Alraouji NN, Siti-Fauziah Hendrayani , Hazem Ghebeh , Falah H Al-Mohanna and Aboussekhra A. Osteoprotegerin (OPG) mediates the anti-carcinogenic effects of normal breast fibroblasts and targets cancer stem cells through inhibition of the β-catenin pathway. Cancer Letters. (2021). 520:374-384. doi: 10.1016/j.canlet.2021.08.013.

20. Naif Al-Jomah, Falah H Al-Mohanna and Abdelilah Aboussekhra. Tocilizumab suppresses the pro-carcinogenic effects of breast cancer- associated fibroblasts through inhibition of the STAT3/AUF1 pathway. Carcinogenesis. (2021). 42:1439-1448. doi: 10.1093/carcin/bgab102.

21. Al-Kharashi LA, Tala Bakheet, Wejdan A AlHarbi, Nisreen Al-Moghrabi and Aboussekhra A. Eugenol modulates genomic methylation and inactivates breast cancer-associated fibroblasts through E2F1-dependent downregulation of DNMT1/DNMT3A. Mol Carcinogenesis. (2021). 60:784-795. doi: 10.1002/mc.23344.

22. Al-Harbi B and Aboussekhra A. Cucurbitacin I (JSI-124)-dependent inhibition of STAT3 permanently suppresses the pro-carcinogenic effects of active breast cancer-associated fibroblasts. Mol Carcinogenesis. (2021). 60(4):242-251. doi: 10.1002/mc.23287. PMID: 33621387.

23. Alraouji NN and Aboussekhra A. Tocilizumab inhibits IL-8 and the proangiogenic potential of triple negative breast cancer cells. Mol Carcinogenesis. (2021). 60(1):51-59. doi: 10.1002/mc.23270.

24. Manar M. AlAhmari, Huda H. Al-Khalaf, Falah H. Al-Mohanna, Hazem Ghebeh and Abdelilah Aboussekhra. AUF1 promotes stemness in human mammary epithelial cells through stabilization of the EMT transcription factors TWIST1 and SNAIL1. Oncogenesis. (2020). 9(8): 70. doi: 10.1038/s41389-020-00255-1.

25. Alraouji NN, Al-Mohanna FH, Ghebeh H, Arafah M, Almeer R, Al-Tweigeri T, Aboussekhra A. Tocilizumab potentiates cisplatin cytotoxicity and targets cancer stem cells in triple-negative breast cancer. Mol Carcinog. (2020). 59(9):1041-1051. doi: 10.1002/mc.23234.

26. Al-Ansari MM, Al-Saif M, Arafah M, Eldali AM, Tulbah A, Al-Tweigeri T, Semlali A, Khabar KS and Aboussekhra A. Clinical and functional significance of tumor/stromal ATR expression in breast cancer patients. Breast Cancer Res. (2020), May 15;22(1):49.

27. Al-Khalaf HH, Ghebeh H, Wakil SM, Al-Mohanna F, Aboussekhra A. Interleukin-8 Dedifferentiates Primary Human Luminal Cells to Multipotent Stem Cells. Mol Cell Biol. (2020),13;40(9):e00508-19.

28. Huda H. Al-Khalaf, Hazem Ghebeh, Rabia Inass, Abdelilah Aboussekhra. Senescent Breast Luminal Cells Promote Carcinogenesis through Interleukin-8-Dependent Activation of Stromal Fibroblasts. Mol Cell Biol. (2019), Jan 3;39(2). pii: e00359-18.

29. Breast Cancer-Associated Adipocytes and Promotes Their Angiogenesis- and Tumorigenesis-Promoting Effects. Mol Cell Biol. (2019), 3;39(2). pii: e00332-18.

30. Isalm SS and Aboussekhra A. Sequential combination of cisplatin with eugenol targets ovarian cancer stem cells through the Notch-Hes1 signaling pathway. J Exp Clin Cancer Res. (2019), 30;38(1):382. doi: 10.1186/s13046019-1360-3.

31. Al-Khalaf HH, Aboussekhra A. AUF1 positively controls angiogenesis through mRNA stabilization-dependent up-regulation of HIF-1α and VEGF-A in human osteosarcoma. Oncotarget; (2019). 10(47):4868-4879.

32. Mysoon M. Al-Ansari, and Abdelilah Aboussekhra. ATR suppresses the pro-tumorigenic functions of breast stromal fibroblasts. Oncotarget. (2018); 9:34681-34690.

33. Al-Khalaf HH, Aboussekhra A. p16 Controls p53 Protein Expression Through miR-dependent Destabilization of MDM2. Mol. Cancer Res. (2018), 16(8):1299-1308.

34. Islam SS, Al-Sharif I, Sultan A, Al-Mazrou A, Remmal A, Aboussekhra A. Eugenol potentiates cisplatin anticancer activity through inhibition of ALDH-positive breast cancer stem cells and the NF-κB signaling pathway. Mol. Carcinogenesis. (2018). 57(3):333-346.

35. Al-Harbi B, Hendrayani SF, Silva G, Aboussekhra A. Let-7b inhibits cancer-promoting effects of breast cancerassociated fibroblasts through IL-8 repression. Oncotarget. (2018), 3;9(25):17825-17838.

36. Al-Kharashi LA, Al-Mohanna FH, Tulbah A, Aboussekhra A. The DNA methyl-transferase protein DNMT1 enhances tumor-promoting properties of breast stromal fibroblasts. Oncotarget. (2017), 18;9(2):2329-2343.

37. Al-Khalaf HH, Amir M, Al-Mohanna F, Tulbah A, Al-Sayed A, Aboussekhra A. Obesity and p16INK4A Downregulation Activate Breast Adipocytes and Promote Their Protumorigenicity. Mol Cell Biol. (2017). 11;37(17). pii: e00101-17.

38. Al-Khalaf HH, Nallar SC, Kalvakolanu DV, Aboussekhra A. p16INK4A enhances the transcriptional and the apoptotic functions of p53 through DNA-dependent interaction. Mol. Carcinogenesis. (2017), 56(7):1687-1702.

39. Al-Khalaf HH, Aboussekhra A. p16INK4A induces senescence and inhibits EMT through microRNA141/microRNA-146b-5p-dependent repression of AUF1. Mol. Carcinogenesis. (2017), 56(3):985-999.

40. Noman AS, Uddin M, Chowdhury AA, Nayeem MJ, Raihan Z, Rashid MI, Azad AK, Rahman ML, Barua D, Sultana A, Shirin A, Ferdous J, Parag RR, Rahman SM, Mahmud MR, Jerin CS, Jahan N, Siddiqua A, Ara T, Sabur EB, Alam SS, Baidya S, Akther S, Rahman MZ, Banu T, Murugan AK, Sabri S, Islam SMS, Karakas B, Aboussekhra A, Yeger H, Farhat WA, Islam SS. Serum sonic hedgehog (SHH) and interleukin-(IL-6) as dual prognostic biomarkers in progressive metastatic breast cancer. Sci Rep. (2017), May 11;7(1):1796.

41. Hendrayani SF, Al-Harbi B, Al-Ansari MM, Silva G, Aboussekhra A. The inflammatory/cancer-related IL-6/STAT3/NF-κB positive feedback loop includes AUF1 and maintains the active state of breast myofibroblasts. Oncotarget. (2016). 7:41974-41985.

42. Al-Howail HA, Hakami HA, Al-Otaibi B, Al-Mazrou A, Daghestani MH, Al-Jammaz I, Al-Khalaf HH, Aboussekhra A. PAC down-regulates estrogen receptor alpha and suppresses epithelial-tomesenchymal transition in breast cancer cells. BMC Cancer. (2016). doi: 10.1186/s12885-016-2583-8.

43. Al-Rakan MA, Hendrayani SF, Aboussekhra A. CHEK2 represses breast stromal fibroblasts and their paracrine tumor-promoting effects through suppressing SDF-1 and IL-6. BMC Cancer. (2016) doi: 10.1186/s12885-016-2614-5.

44. Silva G, Aboussekhra A. p16(INK4A) inhibits the pro-metastatic potentials of osteosarcoma cells through targeting the ERK pathway and TGF-β1. Mol Carcinogenesis. (2016), 55(5):525-536.

45. Noman AS, Uddin M, Rahman MZ, Nayeem MJ, Alam SS, Khatun Z, Wahiduzzaman M, Sultana A, Rahman ML, Ali MY, Barua D, Ahmed I, Islam MS, Aboussekhra A, Yeger H, Farhat WA, Islam SS. Overexpression of sonic hedgehog in the triple negative breast cancer: clinicopathological characteristics of high burden breast cancer patients from Bangladesh. Sci Rep. (2016) 5;6:18830.

46. Abeer Al-Qasem, Huda A. Al-Howail, Mashael Al-Swailem, Amer Al-Mazrou, Basem Al-Otaibi, Ibrahim AlJammaz, Huda H. Al-Khalaf and Abdelilah Aboussekhra. PAC exhibits potent anti-colon cancer properties through targeting cyclin D1 and suppressing epithelial-to-mesenchymal transition.Mol. Carcinogenesis. (2016) Mar;55(3):233-44.

47. Al-Ansari MM and Aboussekhra A. miR-146b-5p mediates p16-dependent repression of IL-6 and suppresses paracrine procarcinogenic effects of breast stromal fibroblasts. (2015) Oncotarget. Oct 6;6(30):30006-16.

48. Hendrayani SF, Al-Khalaf HH, Aboussekhra A. The cytokine IL-6 reactivates breast stromal fibroblasts through transcription factor STAT3-dependent up-regulation of the RNA-binding protein AUF1. J. Biol Chem. (2014). 289(45):31433-31447.

49. Al-Khalaf HH, and Aboussekhra A. MicroRNA-141 and microRNA-146b-5p inhibit the prometastatic mesenchymal characteristics through the RNA-binding protein AUF1 targeting the transcription factor ZEB1 and the protein kinase AKT. J. Biol Chem. (2014). 289(45):30962-30976.

50. Nisreen Al-Moghrabi, Asmaa Nofel, Nujoud Al-Yousef, Safia Madkhali, Suad M Bin Amer, Ayodele Alaiya, Zakia Shinwari, Taher Al-Tweigeri, Bedri Karakas, Asma Tulbah and Abdelilah Aboussekhra. The molecular significance of methylated BRCA1 promoter in white blood cells of cancer-free females. BMC Cancer. (2014). doi:10.1186/1471-2407-14-830.

51. Al-Khalaf HH, and Aboussekhra A. ATR controls the UV-related upregulation of the CDKN1A mRNA in a Cdk1/HuR-dependent manner. Mol Carcinogenesis. (2014). 53:979-987.

52. Elkum N, Al-Tweigeri T, Ajarim D, Al-Zahrani A, Amer SM, Aboussekhra A. Obesity is a significant risk factor for breast cancer in Arab women. BMC Cancer. (2014), 29;14:788.

53. Al-Ansari MM and Aboussekhra A. Caffeine Mediates Sustained Inactivation of Breast CancerAssociated Myofibroblasts via Up-Regulation of Tumor Suppressor Genes. PLoS One. (2014) 3;9(3):e90907. doi: 10.1371.

54. Al-Sharif I, Remmal A, Aboussekhra A. Eugenol triggers apoptosis in breast cancer cells through E2F1/survivin down-regulation.) BMC Cancer. (2014), 13;13:600. doi: 10.1186/1471-2407-13-600.

55. Al-Khalaf HH, Mohideen P, Nallar SC, Kalvakolanu DV, Aboussekhra A. The Cyclin-dependent.

56. Kinase Inhibitor p16INK4a Physically Interacts with Transcription Factor Sp1 and Cyclin-dependent Kinase 4 to Transactivate MicroRNA-141 and MicroRNA-146b-5p Spontaneously and in Response to Ultraviolet Light-induced DNA Damage. J. Biol Chem. (2013), 288(49):35511-25.

57. Al-Ansari MM, Hendrayani SF, Shehata AI, Aboussekhra A. p16(INK4A) Represses the paracrine tumorpromoting effects of breast stromal fibroblasts. Oncogene. (2013), 32 (18) 2356-2364.

58. Al-Rakan MA, Colak D, Hendrayani SF, Al-Bakheet A, Al-Mohanna FH, Kaya N, Al-Malik O, Aboussekhra A. Breast stromal fibroblasts from histologically normal surgical margins are pro-carcinogenic. J Pathol. (2013), 231:457-465.

59. Hendrayani SF, Al-Khalaf HH, Aboussekhra A. Curcumin Triggers p16-Dependent Senescence in Active Breast Cancer-Associated Fibroblasts and Suppresses Their Paracrine Procarcinogenic Effects. Neoplasia. (2013), 16(6):631-640.

60. Al-Khalaf HH, Aboussekhra A. Survivin expression increases during aging and enhances the resistance of aged human fibroblasts to genotoxic stress. AGE. (2013), 35(3):549-562.

61. Al-Khalaf HH, Aboussekhra A. p16(INK4A) Positively Regulates p21(WAF1) Expression by suppressing AUF1-dependent mRNA decay. PLoS One. (2013), 23;8(7):e70133.

62. Al-Khalaf HH, Hendrayani SF, Aboussekhra A*. ATR controls the p21(WAF1/Cip1) protein upregulation and apoptosis in response to low UV fluences. Mol. Carcinog. (2013), 51(12):930-938.

63. Karakas B, Colak D, Kaya N, Ghebeh H, Al-Qasem A, Hendrayani F, Toulimat M, Al-Tweigeri T, Park BH, Aboussekhra A. Prevalence of PIK3CA mutations and the SNP rs17849079 in Arab breast cancer patients. Cancer Biol. Ther. (2013),14(10): 888-896.

64. Elamin MH, Daghestani MH, Omer SA, Elobeid MA, Virk P, Al-Olayan EM, Hassan ZK, Mohammed OB, Aboussekhra A. Olive oil oleuropein has anti-breast cancer properties with higher efficiency on ER-negative cells. Food and Chem Toxicol. (2013), 53:310-6.

65. Al-Ansari MM, Hendrayani SF, Tulbah A, Al-Tweigeri T, Shehata AI, Aboussekhra A. p16INK4A represses breast stromal fibroblasts migration/invasion and their VEGF-A-dependent promotion of angiogenesis through Atk inhibition. Neoplasia. (2012),14(12):1269-77.

66. Al-Khalaf HH, Hendrayani SF, Aboussekhra A. ATR controls the p21(WAF1/Cip1) protein upregulation and apoptosis in response to low UV fluences. Mol Carcinogenesis. (2012), 15:930-938.

67. Al-Yousef N, Gaafar A, Al-Otaibi B, Al-Jammaz I, Al-Hussein K, Aboussekhra A. Camel urine components display anti-cancer properties in vitro. J. Ethnopharmacology. (2012),11: 819-825.

68. Abeer J. Al-Qasem, Mohamed Toulimat, Asma Tulbah, Naser ElKum, Taher Al-Tweigeri and Abdelilah Aboussekhra. The p53 codon 72 polymorphism is associated with risk and early onset of breast cancer among Saudi women. Oncology Letters. (2012), 3: 875-878.

69. Al-Khalaf HH, Colak D, Al-Saif M, Al-Bakheet A, Hendrayani SF, Al-Yousef N, Kaya N, Khabar KS, Aboussekhra A. p16 Positively Regulates Cyclin D1 and E2F1 through Negative Control of AUF1. PLoS One. (2011), 6(7):e21111.

70. Al-Khalaf HH, Hendrayani SF, Aboussekhra A. The Atr protein kinase controls UV-dependent up-regulation of p16INK4A through inhibition of Skp2-related polyubiquitination/degradation. Mol Cancer Res. (2011), 9: 311319.

71. Al-Hujaily EM, Mohamed AG, Al-Sharif I, Youssef KM, Manogaran PS, Al-Otaibi B, Al-Haza'a A, Al-Jammaz I, Al-Hussein K, Aboussekhra A. PAC, a novel curcumin analogue, has anti-breast cancer properties with higher efficiency on ER-negative cells. Breast Cancer Res. & Treat. (2011), 128: 97-107.

72. Shinwari Z, Al-Hindi H, Al-Shail E, Khafaga Y, Al-Kofide A, El-Kum N, Aboussekhra A*. Response of Medulloblastoma Cells to Vincristine and Lomustine: Role of TRKC, CTNNB1 and STK15. Anticancer Res. (2011), 31(5):1721-33.

73. Al-Moghrabi N*, Al-Qasem AJ, Aboussekhra A. Methylation-related mutations in the BRCA1 promoter in peripheral blood cells from cancer-free women. Int J Oncol. (2011), 39(1):129-35.

74. Abeer J. Al-Qasem, Mohamed Toulimat, Abdelmoneim M. Eldali, Asma Tulbah, Nujoud Al-yousef, Sooad K. Al-Daihan, Nada Al-Tassan, Taher Al-Tweigeri and Abdelilah Aboussekhra.TP53 genetic alterations in the Arab breast cancer patients: Novel mutations, pattern and distribution. Oncology Letters. (2011), 2: 363-369.

75. Ghebeh H, Lehe C, Barhoush E, Al-Romaih K, Tulbah A, Al-Alwan M, Hendrayani SF, Manogaran P, Alaiya A, Al-Tweigeri T, Aboussekhra A, Dermime S. Doxorubicin downregulates cell surface B7-H1 expression and upregulates its nuclear expression in breast cancer cells: role of B7-H1 as an anti-apoptotic molecule. Breast Cancer Res. (2010), 12(4):R48.

76. Maha H. Elamin, Zakia Shinwari, Siti-Faujiah Hendrayani, Hindi Al-Hindi, Essam Al-Shail, Yasser khafaga, Amani Al-kofide and Abdelilah Aboussekhra. Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells. Mol. Carcinogenesis. (2010), 49:302-314.

77. Nisreen M. Al-Moghrabi, Ibtehaj S. Al-Sharif and Abdelilah Aboussekhra. The RAD9-dependent gene transactivation is required for excision repair of active genes but not for repair of non-transcribed DNA. Mutation Research. (2009), 663:60-68.

78. Nahed M. Hawsawi, Hazem Ghebeh, Siti-Faujiah Hendrayani, Asma Tulbah, Maha Al-Eid, Taher Al-Tweigeri, Dahish Ajarim, Ayodele Alaiya, Said Dermime and Abdelilah Aboussekhra. Breast carcinoma-associated fibroblasts and their counterparts display neoplastic-specific changes. Cancer Res. (2008), 8: 2717-2725.

79. Zakia Shinwari, Pulicat S. Manogaran, Salman A. Alrokayan, Khaled Al-Hussein and Abdelilah Aboussekhra.Vincristine and lomustine induce apoptosis and p21(WAF1) up-regulation in medulloblastoma and normal human epithelial and fibroblast cells. J. Neuro-Oncology. (2008), 87:123-132.

80. Huda H. Al-Khalaf, Boleslaw Lach, Ayman Allam, Maher Hassounah, Ahmed AlKhani, Nasser Elkum, Salman A. Alrokayan and Abdelilah Aboussekhra. Expression of survivin and p16(INK4a)/Cdk6/pRB proteins and induction of apoptosis in response to radiation and cisplatin in meningioma cells. Brain Res. (2008), 1188:25-34.

81. Mai A. Al-Mohanna, Huda H. Al-Khalaf, Nujoud Al-Yousef and Abdelilah Aboussekhra. The p16INK4a tumor suppressor controls p21WAF1 induction in response to ultraviolet light. Nucleic Acids Res. (2007), 35:223-33.

82. Huda H. Al-Khalaf, Boleslaw Lach, Ayman Allam, Ahmed AlKhani, Salman A. Alrokayan and Abdelilah Aboussekhra. The p53/p21 DNA damage-signaling pathway is defective in most meningioma cells. J. NeuroOncology. (2007), 83:9-15.

83. Abdelilah Aboussekhra and Ibtehaj S. Al-Sharif. Homologous recombination is involved in transcriptioncoupled repair of UV damage in Saccharomyces cerevisiae. EMBO J, (2005), 24, 1999-2010.

84. Maher Hassounah, Boleslaw Lach, Ayman Allam, Huda Al-Khalaf, Yunuss Siddiqui, Nancy Pangue-Cruz, Abeer Al-Omeir, Mohammed N. Al-Ahdal and Abdelilah Aboussekhra. Benign tumors from the human nervous system express high levels of survivin and are resistant to spontaneous and radiation-induced apoptosis. J. NeuroOncology. (2005), 72. 203-208.

85. Chami N, Bennis S, Chami F, Aboussekhra A and Remmal A. Study of anticandidal activity of carvacrol and eugenol in vitro and in vivo. Oral Microbiol Immunol. (2005), 20.106-11.

86. Mai A. Al-Mohanna, Pulicat S. Manogaran, Zuha Al-Mukhalafi, Khaled Al-Hussein and Abdelilah Aboussekhra. The tumor suppressor p16INK4a gene is a regulator of apoptosis induced by ultraviolet light and cisplatin. Oncogene. (2004), 23. 201-212.

87. Nisreen M. Al-Moghrabi, Ibtehaj S. Al-Sharif and Abdelilah Aboussekhra. UV-induced de novo protein synthesis enhances nucleotide excision repair efficiency in a transcription-dependent manner in S.cerevisiae Mutation Research-DNA repair. (2003), 2.1185-1197.

88. Mohammed A. Hannan, Ali Hellani, Fahad M. Al-Khodairy, Mohammed Kunhi, Yunis Siddiqui, Noujud AlYussef, Nancy Prague-Cruz, Monica Siewertsen, Mohammed N. Al-Ahdal and Abdelilah Aboussekhra. Deficiency in the repair of UV-induced DNA damage in human skin fibroblasts compromised for the ATM gene. Carcinogenesis. (2002), 23, 1617-1624.

89. Al-Moghrabi NM, Al-Sharif IS and Aboussekhra A. The Saccharomyces cerevisiae RAD9 cell cycle checkpoint gene is required for optimal repair of UV-induced pyrimidine dimers in both G(1) and G(2)/M phases of the cell cycle. Nucleic Acids Res. (2001), 15, 2020-5.

90. Al-Mohanna MA, Al-Khodairy FM, Krezolek Z, Bertilsson PA, Al-Houssein KA and Aboussekhra A. p53 is dispensable for UV-induced cell cycle arrest at late G(1) in mammalian cells. Carcinogenesis. (2001), 22, 573-8.

91. Aboussekhra, A., and Thoma, F. TATA-binding protein promotes the selective formation of UV-induced (6-4)photoproducts and modulates DNA repair in the TATA box. EMBO J. (1999), 18, 433-43.

92. Aboussekhra, A., and Thoma, F. Nucleotide excision repair and photolyase preferentially repair the nontranscribed strand of RNA polymerase III-transcribed genes in Saccharomyces cerevisiae. Genes & Dev. (1998), 12, 411-21.

93. K Sugasawa, JM Ng, C Masutani, T Maekawa, A Uchida, PJ van der Spek, AP Eker, S Rademakers, C Visser, A Aboussekhra, RD Wood, F Hanaoka, D Bootsma and JH Hoeijmakers. Two human homologs of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity. Mol. Cell Biol. (1997), 17, 6924-6931.

94. Aboussekhra, A., Vialard, J. E., Morrison, D. E., de la Torre-Ruiz, M. A., Cernakova, L., Fabre, F., and Lowndes, N. F. A novel role for the budding yeast RAD9 checkpoint gene in DNA damage- dependent transcription. EMBO J. (1996), 15, 3912-22.

95. Aboussekhra, A., Biggerstaff, M., Shivji, M. K., Vilpo, J. A., Moncollin, V., Podust, V. N., Protic, M., Hubscher, U., Egly, J. M., and Wood, R. D. Mammalian DNA nucleotide excision repair reconstituted with purified protein components. Cell. (1995), 80, 859-68.

96. Aboussekhra, A., and Wood, R. D. Detection of nucleotide excision repair incisions in human fibroblasts by immunostaining for PCNA. Exp. Cell Res. (1995), 221, 326-32.

97. Aboussekhra, A., Chanet, R., Adjiri, A., and Fabre, F. Semidominant suppressors of Srs2 helicase mutations of Saccharomyces cerevisiae map in the RAD51 gene, whose sequence predicts a protein with similarities to procaryotic RecA proteins. Mol. Cell Biol. (1992), 12, 3224-34.

98. Aboussekhra, A., Chanet, R., Zgaga, Z., Cassier-Chauvat, C., Heude, M., and Fabre, F. RADH, a gene of Saccharomyces cerevisiae encoding a putative DNA helicase involved in DNA repair. Characteristics of radH mutants and sequence of the gene. Nucleic Acids Res. (1989), 17, 7211-9.

1. A. Aboussekhra, I. AL-Jammaz, N. Alraouji, B. Al-Otaibi. Cisplatin analogue with potent Anti-cancer effects and synthesis thereof. August 2025 (EP4311830B1).

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4. A. Aboussekhra, T. Al-Tweigeri, N. Alraouji. Combination of an anti-interleukin-6 receptor antibody, a platinum based antineoplastic drug, and a taxane. Filed in USA (# 18_122,839), Europe (# 23_162_694.6) and KSA.