Unnatural Oligonucleotides for RNA Therapeutics

Unnatural oligonucleotides represent a frontier in RNA therapeutics, offering enhanced stability, specificity and functionality beyond the limits of natural nucleic acids. By incorporating chemically modified backbones, bases or sugars, we are developing synthetic constructs that resist nuclease degradation and evade immune recognition, enabling more durable and targeted interventions. They are pivotal in advancing antisense oligonucleotides, siRNA, and mRNA-based therapies, particularly for diseases whereby conventional modalities fall short. At the interface of synthetic biology and precision medicine, unnatural oligonucleotides are defining the therapeutic landscape, unlocking new possibilities for treating genetic, infectious and degenerative diseases with unprecedented control and efficiency.